Description
Product Characteristics: POLR3H antibody, KIAA1665 antibody, RPC8 antibody, DNA-directed RNA polymerase III subunit RPC8 antibody, RNA polymerase III subunit C8 antibody, DNA-directed RNA polymerase III subunit H antibody, RNA polymerase III subunit 22.9 kDa subunit antibody, RPC22.9 antibody
Target Information: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNA. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa- B through the RIG-I pathway (By similarity)